Generation of retroviral packaging and producer cell lines for large-scale vector production and clinical application: improved safety and high titer
This paper, cited 70 times, describes improvements in retroviral vector packaging and producer cell lines designed to yield higher unprocessed manufacturing titers, complement-resistant vectors, and minimize the potential to generate replication-competent retrovirus (RCR). I was involved in developing and validating the titer assays and the RCR tests used to evaluate the cell lines.
