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You are here: Home1 » Blog2 » Publications3 » Generation of retroviral packaging and producer cell lines for large-scale...

Generation of retroviral packaging and producer cell lines for large-scale vector production and clinical application: improved safety and high titer

Publications September 1, 2000

This paper, cited 70 times, describes improvements in retroviral vector packaging and producer cell lines designed to yield higher unprocessed manufacturing titers, complement-resistant vectors, and minimize the potential to  generate  replication-competent  retrovirus  (RCR).  I was involved in developing and validating the titer assays and the RCR tests used to evaluate the cell lines.

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Development of retroviral‐based gene therapy products: a quality control ...Working toward an adenoviral vector testing standard
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