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Co-chair panel Bioassays and statistics FAQs to FACTS

In this session, Nancy Sajjadi and Steve Walfish introduce 4 speakers and posit several questions to address hot topics in bioassay design, development and validation:  Generating and evaluating the standard curve, establishing equivalence…

Evidence for localization of biologically active recombinant retroviral vector to lymph nodes in mice injected intramuscularly.

Results of these studies indicated that the localization of retroviral DNA to the injection site and regional lymph nodes may play a role in the induction of the product directed, specific CTL responses detected in splenocyte populations isolated…

Recombinant retroviral vector interferes with the detection of amphotropic replication competent retrovirus in standard culture assays

This paper has been cited over 40 times.  It summarizes studies that revealed that recombinant retroviral vector can interfere with the detection of low-level RCR in culture and that such interference can be partially overcome by culturing…

Recombinant retroviral vector delivered intramuscularly localizes to the site of injection in mice

Two of the main safety considerations associated with the direct administration of recombinant retrovirus are the generation of replication-competent retrovirus in vector-producing cell lines and inadvertent germ-line transduction. In this early…