For over 30 years, I have been involved in the quality control of experimental biologics and have witnessed both incredible outcomes and tragic disappointments in addressing many different unmet clinical needs. I recently attended a conference…
https://sajjadiconsulting.com/wp-content/uploads/2021/09/Nancy-headshot-340x340-1.jpg340340Jill Kurtzhttps://sajjadiconsulting.com/wp-content/uploads/2021/08/sajjadi-logo-web.pngJill Kurtz2022-11-02 11:05:532022-11-02 11:05:53Developments in Bioassays
This paper summarizes work to character vector immunogenicity. Studies showed that intramuscular (i.m.) administration of retroviral vector induces strong anti-vector Ig responses, in a dose-dependent fashion. Although such anti-vector Ig was…
https://firstname.lastname@example.org://email@example.com 15:29:512021-09-28 09:26:35Anti-vector immunoglobulin induced by retroviral vectors
Results of these studies indicated that the localization of retroviral DNA to the injection site and regional lymph nodes may play a role in the induction of the product directed, specific CTL responses detected in splenocyte populations isolated…
https://firstname.lastname@example.org://email@example.com 16:00:122021-09-28 09:27:07Evidence for localization of biologically active recombinant retroviral vector to lymph nodes in mice injected intramuscularly.
This paper has been cited over 40 times. It summarizes studies that revealed that recombinant retroviral vector can interfere with the detection of low-level RCR in culture and that such interference can be partially overcome by culturing…
https://firstname.lastname@example.org://email@example.com 15:29:012021-09-28 09:28:21Recombinant retroviral vector interferes with the detection of amphotropic replication competent retrovirus in standard culture assays
Two of the main safety considerations associated with the direct administration of recombinant retrovirus are the generation of replication-competent retrovirus in vector-producing cell lines and inadvertent germ-line transduction. In this early…
https://firstname.lastname@example.org://email@example.com 15:59:302021-09-28 09:28:50Recombinant retroviral vector delivered intramuscularly localizes to the site of injection in mice
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